Dominant DNA Motion

Minor groove view of ensemble average structures for TATA-variants over 2.4 ns DNA/ion/water simulations.
(global helical axes displayed)

Full range of motion along first principal component
WT & T26: Mgroove bending
A29: mgroove bending

(For detailed information, see the article "Dynamic Simulations of 13 TATA Variants Refine Kinetic Hypotheses on Sequence/Activity Relationships", X. Qian, D. Strahs, and T. Schlick, J. Mol. biol., In Press 2001).